Wednesday, January 30, 2013

Monkeys in space: A brief history

If Iran has indeed launched a monkey to space, the nation is following a path similar to that taken by the United States in the early days of its space program.

Iran announced Monday that it had successfully launched a live monkey on a spaceflight and recovered the animal alive after landing. The move is a prelude to sending humans into space, which the Islamic Republic hopes to do by 2020, Iranian Space Agency officials said.

Iran and the United States don't see eye-to-eye on many issues, but both have viewed monkeys as good astronaut test subjects over the years. The U.S. was the first country ever to launch a primate, sending a rhesus monkey named Albert to a sub-space altitude of 39 miles aboard a V2 rocket in June 1948.

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Very little was known about the physiological effects of spaceflight back in those days, with some scientists postulating that astronauts' cardiovascular systems would fail in the microgravity environment, causing near-instant death. So researchers wanted to blast some relatively large animals into space to see how they fared. [ Giant Leaps: Top Milestones of Human Spaceflight ]

Albert died of suffocation during his flight, and a number of his simian brethren also sacrificed their lives to the cause in the ensuing years.

Another rhesus monkey named Albert II, for example, became the first primate to reach space, achieving an altitude of 83 miles aboard another V2 in June 1949. He survived the launch but died after a parachute failure caused his capsule to slam hard into the ground.

Alberts III and IV died during their missions in late 1949, and Albert V was victimized by another parachute failure in 1951. Albert VI, also known as Yorick, survived his 1951 flight, though it topped out at an altitude of just 45 miles ? significantly below the generally accepted 62-mile boundary demarcating outer space.

Yorick died several hours after landing, possibly from heat stress suffered as he sat inside his cramped capsule in the New Mexico sun, waiting for the recovery crew.

The United States recorded a milestone in May 1959, finally recovering two primates alive after a spaceflight. A rhesus monkey named Able and a squirrel monkey named Baker reached an altitude of 300 miles aboard a Jupiter rocket and were retrieved unharmed. (Sadly, Able died several days later during an operation to remove an electrode from under her skin.)

As the American human spaceflight program began to build momentum, the nation started experimenting with chimpanzees, which are larger and more closely related to humans than are rhesus, squirrel or other monkeys.

The U.S. launched a chimp named Ham on a suborbital spaceflight on Jan. 31, 1961. Ham reached an altitude of 157 miles during a 16.5-minute flight and was recovered unharmed, though a bit dehydrated. With this success in hand, Alan Shepard successfully blasted off on his suborbital flight on May 5, 1961, becoming the first American ? and second human, after the Soviet Union's Yuri Gagarin ? ever to reach space.

A chimp named Enos orbited the Earth on Nov. 29, 1961, paving the way for John Glenn's historic orbital flight of Feb. 20, 1962. (Again, the U.S. was slightly late to the party: Gagarin orbited our planet on his flight of April 12, 1961.)

After it became established that humans could indeed survive the rigors of spaceflight, monkeys and apes faded into the background. The U.S. continued to launch animals for scientific experiments but increasingly concentrated on smaller creatures such as mice and insects, which are easier to care for and take up much less space (although two squirrel monkeys did ride on the space shuttle Challenger 's STS-51-B mission in April-May 1985.)

The United States' space race rival, the Soviet Union, primarily used dogs in the run-up to its first human launches, thinking that canines would prove to be less fidgety in flight than monkeys.

The Soviets launched their first dogs to space in 1951. The nation famously succeeded in lofting the first animal ? a dog called Laika ("Barker") ? to orbit aboard the Sputnik 2 spacecraft in November 1957. (Laika died during the flight.)

Despite its canine focus, the Soviet Union and its successor state Russia did launch a number of rhesus monkeys to space in the 1980s and 1990s, as part of a program called Bion. France also blasted two pig-tailed macaque monkeys to suborbital space in 1967.

Iran's recent launch was not its first attempt to send a monkey into space. A previous orbital effort in 2011 failed.

Follow SPACE.com senior writer Mike Wall on Twitter@michaeldwall or SPACE.com@Spacedotcom. We're also on Facebook and Google+.

? 2013 Space.com. All rights reserved. More from Space.com.

Source: http://www.nbcnews.com/id/50620102/ns/technology_and_science-space/

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Doctor-patient relationship: Physicians' brain scans indicate doctors can feel their patients' pain -- and their relief

Jan. 29, 2013 ? A patient's relationship with his or her doctor has long been considered an important component of healing. Now, in a novel investigation in which physicians underwent brain scans while they believed they were actually treating patients, researchers have provided the first scientific evidence indicating that doctors truly can feel their patients' pain -- and can also experience their relief following treatment.

Led by researchers at Massachusetts General Hospital (MGH) and the Program in Placebo Studies and Therapeutic Encounter (PiPS) at Beth Israel Deaconess Medical Center/Harvard Medical School, the new findings, which appear online? January 29 in Molecular Psychiatry, help to illuminate one of the more intangible aspects of health care -- the doctor/patient relationship.

"Our findings showed that the same brain regions that have previously been shown to be activated when patients receive placebo therapies are similarly activated in the brains of doctors when they administer what they think are effective treatments," explains first author Karin Jensen, PhD, an investigator in the Department of Psychiatry and Martinos Center for Biological Imaging at MGH and member of the PiPS. Notably, she adds, the findings also showed that the physicians who reported greater ability to take things from the patients' perspective, that is, to empathize with patients' feelings, experienced higher satisfaction during patients' treatments, as reflected in the brain scans.

"By demonstrating that caring for patients involves a complex set of brain events, including deep understanding of the patient's facial and body expressions, possibly in combination with the physician's own expectations of relief and feelings of reward, we have been able to elucidate the neurobiology underlying caregiving," adds senior author Ted Kaptchuk, director of the PiPS and Associate Professor of Medicine at Harvard Medical School. "Our findings provide early evidence of the importance of interacting brain networks between patients and caregivers and acknowledge the doctor/patient relationship as a valued component of health care, alongside medications and procedures."

Previous investigations have demonstrated that a brain region associated with pain relief (right ventrolateral prefrontal cortex, VLPFC) and a region associated with reward (rostral anterior cingulate cortex, rACC) are activated when patients experience the placebo effect, which occurs when patients show improvement from treatments that contain no active ingredients. The placebo effect accounts for significant portions of clinical outcomes in many illnesses -- including pain, depression and anxiety.

Although behavioral research has suggested that physicians' expectations influence patients' clinical outcomes and help determine patients' placebo responses, until now little effort has been directed to understanding the biology underlying the physician component of the clinical relationship. Jensen and her colleagues hypothesized that the same brain regions that are activated during patients' placebo responses -- the VLPFC and rACC -- would similarly be activated in the brains of physicians as they treated patients. They also hypothesized that a physician's perspective-taking skills would influence the outcomes.

To test these hypotheses, the scientists developed a unique equipment arrangement that would enable them to conduct functional magnetic resonance imaging (fMRI) of the physicians' brains while the doctors had face-to-face interactions with patients, including observing patients as they underwent pain treatments.

The experiment included 18 physicians (all of whom had received their medical degree within the last 10 years and represented nine separate medical specialties). Two 25-year-old females played the role of "patients" and followed a rehearsed script. The experiment called for the participating physicians to administer pain relief with what they thought was a pain-relieving electronic device, but which was actually a non-active "sham" device.

To ensure that the physicians believed that the sham device really worked, the investigators first administered a dose of "heat pain" to the physicians' forearms to gauge pain threshold and then "treated" them with the fake machine. During the treatments, the investigators reduced the heat stimulation, to demonstrate to the participants that the therapy worked. The physicians underwent fMRI scans while they experienced the painful heat stimulation so that investigators could see exactly which brain regions were activated during first-person perception of pain.

In the second portion of the experiment,each physician was introduced to a patient and asked to perform a standardized clinical examination, which was conducted in a typical exam room for approximately 20 minutes. (The clinical exam was performed in order to establish a realistic rapport between the physician and patient before fMRI scanning took place, and was comparable to a standard U.S. doctor's appointment.) At this point the physician also answered a questionnaire, the Interpersonal Reactivity Index, used to measure the participant's self-reported perspective-taking skills.

During the third step, says Jensen, the physician and patient were led into the scanner room. "The physician went inside the scanner and was equipped with a remote control that could activate the 'analgesic device' when prompted," she explains. Mirrors inside the scanner enabled physicians to maintain eye contact with the patient, who was seated on a chair next to the scanner's bed and hooked up to both the thermal pain stimulator and the pain-relieving device.

Then, in a randomized order, physicians were instructed to either treat a patient's pain or to press a control button that provided no relief. When physicians were told not to activate pain relief, the "patient" exhibited a painful facial expression while the physicians watched. When the physicians were instructed to treat the patients' pain, they could see that the subjects' faces were neutral and relaxed, the result of pain relief. During these doctor-patient interactions, fMRI scans measured the doctors' brain activations.

Following the scanning session, the physicians were removed from the scanner and told exactly how the experiment had been performed, says Jensen. "If the physician did not agree with the deceptive component of the study, they were given the opportunity to withdraw their data. No one did this."

As predicted, the authors found that while treating patients, the physicians activated the right VLPFC region of the brain, a region previously implicated in the placebo response. Furthermore, Jensen adds, the physicians' ability to take the patients' viewpoints correlated to brain activations and subjective ratings; physicians who reported high perspective-taking skills were more likely to show activation in the rACC brain region, which is associated with reward.

"We already know that the physician-patient relationship provides solace and can even relieve many symptoms," adds Kaptchuk. "Now, for the first time, we've shown that caring for patients encompasses a unique neurobiology in physicians. Our ultimate goal is to transform the 'art of medicine' into the 'science of care,' and this research is an important first step in this process as we continue investigations to find out how patient-clinician interactions can lead to measurable clinical outcomes in patients."

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Story Source:

The above story is reprinted from materials provided by Beth Israel Deaconess Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. K B Jensen, P Petrovic, C E Kerr, I Kirsch, J Raicek, A Cheetham, R Spaeth, A Cook, R L Gollub, J Kong, T J Kaptchuk. Sharing pain and relief: neural correlates of physicians during treatment of patients. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2012.195

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/w165jz3M4c4/130129080622.htm

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Source: http://www.solutions4ever.net/2013/01/sports-shipping-who-first-crew-times/

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Source: http://barring-columnar.blogspot.com/2013/01/sports-shipping-who-first-crew-times.html

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Tuesday, January 29, 2013

UFC on Fox 6?s Three Stars: Anthony Pettis, Ricardo Lamas and T.J. Grant

In the home of the 6-0 Chicago Blackhawks, the UFC had its sixth showing on Fox. In hockey's tradition, here are the Three Stars from the card.

No. 1 star ? Anthony Pettis: Once upon a time, Pettis was the WEC champion and had a shot at the UFC lightweight title. But then Frankie Edgar and Gray Maynard fought to a draw and required a rematch, and Pettis lost to Clay Guida. But with a nasty liver kick that took out Donald Cerrone, Pettis showed he was still worthy of that title shot.

No. 2 star ? Ricardo Lamas: Speaking of title shots, Lamas made a convincing case on Saturday night for the featherweight belt. He used punishing ground and pound to make Erik Koch's face explode on the way to a TKO. Lamas has four wins in a row, and has earned the shot to be the next fighter with a shot at the featherweight belt after this weekend's fight between Edgar and champion Jose Aldo.

No. 3 star -? T.J. Grant: The lightweight division is stacked, but Grant's showing on Saturday night showed another fighter creeping into the top ranks. He elbowed his way to a win over Matt Wiman.

These are Cagewriter's Three Stars. Who are yours? Speak up in the comments, on Facebook or on Twitter.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ufc-fox-6-three-stars-anthony-pettis-ricardo-142552282--mma.html

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Gas prices rising in New Hampshire

CONCORD, N.H. (AP) -- Gas prices have risen a bit in New Hampshire over the past week.

The average retail price for a gallon of gas averaged $3.44 on Sunday, up 4.2 cents from the past week.

The national average also has increased 4.5 cents in the last week, to $3.31 a gallon.

The website Gasbuddy.com says prices in New Hampshire were a penny per gallon higher than the same day a year ago, and 5.5 cents per gallon higher than a month ago.

The national average is 6.7 cents per gallon lower than a year ago, and 4.5 cents per gallon lower than a month ago.

Source: http://news.yahoo.com/gas-prices-rising-hampshire-160226352.html

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Mormon-founded Marriott supports DOMA repeal. So does eBay, Reuters, Aetna. (Americablog)

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Global Business Trends 2013 - Cross cultural expert, cross cultural ...

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January 27th, 2013

Three Global Business Trends 2013

by Melissa Lamson

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1) Mexico is the next big growth market ?

Brazil, Russia, India and China are still strong and in some cases still steadily growing. However China has almost become too expensive to be considered a growth market anymore, with Brazil close behind,? and many companies are looking for other unexplored markets. Perhaps, surprisingly, Mexico is on the radar screen. The situation has hit rock bottom and politicians have said, ?Enough!? Mexico?s currently looking to revise, revamp and make its mark in 2013 in the world of global business.

2) Social responsibility is at the forefront?

It?s rare to find someone who is successful who isn?t giving back these days and social entrepreneurs are rocking the business world. If you run a large multinational or a small consultancy and you?re not considering what and how you?re conducting business and how your ?social? footprint as well as ?environmental? footprint impacts the world, you won?t relate to this generation?s global workforce nor clientele. Today, people care more about meaning and less about materialism.

3)? Mobile, mobile, mobile! ?

If you have a business, you have to make it easily seen on all devices ? phones, tablets, and the internet. SmartPhones are the absolute norm globally and everyone is accessing information over them first. If you want to be truly global, double-check if your website, store, services, or info is accessible by phone? If not, you?re going to be left behind!

Let us know what you think at www@lamsonconsulting.com

Tags: CSR, global, global business, Global Consultant, Global CSR, Global Trends, Mexico, Mobile, Phone, Social Responsibility, Tablet

Source: http://lamsonconsulting.com/blog/global-business-trends-2013/

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